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No distinct dose adjustment advised when tofacitinib coadministered with strong CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with both equally average CYP3A4 and potent CYP2C19 inhibitors .Modafinil blocks DAT and will cause a boost of dopamine in the animals and human Mind such as the nucleus accumbens, thus inducing the identical